解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and nutrients that may differ from those in which they matured. Imbedded in immune cell physiology are metabolic pathways and metab...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2017.04.004
更新日期:2017-05-04 00:00:00
abstract::The distribution of sense and antisense strand DNA mutations on transcribed duplex DNA contributes to the development of immune and neural systems along with the progression of cancer. Because developmentally matured B cells undergo biologically programmed strand-specific DNA mutagenesis at focal DNA/RNA hybrid struct...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.03.043
更新日期:2017-04-20 00:00:00
abstract::Designing successful microbiota-based therapies requires in-depth understanding of the ecological foundations of this community. In this issue, two studies by Whitaker et al. and Lim et al. provide refined genetic tools for dissecting the spatial organization and temporal dynamics of bacterial communities at the singl...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2017.04.009
更新日期:2017-04-20 00:00:00
abstract::A complex interplay of environmental factors impacts the metabolism of human cells, but neither traditional culture media nor mouse plasma mimic the metabolite composition of human plasma. Here, we developed a culture medium with polar metabolite concentrations comparable to those of human plasma (human plasma-like me...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.03.023
更新日期:2017-04-06 00:00:00
abstract::Scientists are stepping up like never before to support science in the public arena. In big and small ways, scientists are adopting creative ideas to promote science. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.03.029
更新日期:2017-04-06 00:00:00
abstract::Natural killer (NK) cells play a key role in innate immunity by detecting alterations in self and non-self ligands via paired NK cell receptors (NKRs). Despite identification of numerous NKR-ligand interactions, physiological ligands for the prototypical NK1.1 orphan receptor remain elusive. Here, we identify a viral ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.03.002
更新日期:2017-03-23 00:00:00
abstract::Type 2 diabetes (T2D) is a worldwide epidemic with a medical need for additional targeted therapies. Suppression of hepatic glucose production (HGP) effectively ameliorates diabetes and can be exploited for its treatment. We hypothesized that targeting PGC-1α acetylation in the liver, a chemical modification known to ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.03.001
更新日期:2017-03-23 00:00:00
abstract::In the ciliated protozoan Paramecium tetraurelia, Piwi-associated small RNAs are generated upon the elimination of tens of thousands of short transposon-derived DNA segments as part of development. These RNAs then target complementary DNA for elimination in a positive feedback process, contributing to germline defense...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.02.020
更新日期:2017-03-09 00:00:00
abstract::Most secreted growth factors and cytokines are functionally pleiotropic because their receptors are expressed on diverse cell types. While important for normal mammalian physiology, pleiotropy limits the efficacy of cytokines and growth factors as therapeutics. Stem cell factor (SCF) is a growth factor that acts throu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.02.011
更新日期:2017-03-09 00:00:00
abstract::Sexual reproduction is almost universal in eukaryotic life and involves the fusion of male and female haploid gametes into a diploid cell. The sperm-restricted single-pass transmembrane protein HAP2-GCS1 has been postulated to function in membrane merger. Its presence in the major eukaryotic taxa-animals, plants, and ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.01.024
更新日期:2017-02-23 00:00:00
abstract::Targeting of the RAS pathway has long been a critical therapeutic challenge in oncology. Burgess et al. examine how the relative expression of mutant and wild-type KRAS modulates clonal fitness and sensitivity to MEK inhibitors in a model of KrasG12D mutant acute myeloid leukemia and propose its use as a predictive bi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.02.013
更新日期:2017-02-23 00:00:00
abstract::The genetic dependencies of human cancers widely vary. Here, we catalog this heterogeneity and use it to identify functional gene interactions and genotype-dependent liabilities in cancer. By using genome-wide CRISPR-based screens, we generate a gene essentiality dataset across 14 human acute myeloid leukemia (AML) ce...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.01.013
更新日期:2017-02-23 00:00:00
abstract::Cancer immunotherapy can induce long lasting responses in patients with metastatic cancers of a wide range of histologies. Broadening the clinical applicability of these treatments requires an improved understanding of the mechanisms limiting cancer immunotherapy. The interactions between the immune system and cancer ...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2017.01.017
更新日期:2017-02-09 00:00:00
abstract::Clinical trials are key to translating scientific advances into progress in cancer research and care. Confronted by developments in basic science, the landscape of clinical cancer research is rapidly evolving. Here, we review recent changes in clinical trials' design and conduct, and we forecast future directions towa...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.01.027
更新日期:2017-02-09 00:00:00
abstract::The fovea is a specialized region of the retina that dominates the visual perception of primates by providing high chromatic and spatial acuity. While the foveal and peripheral retina share a similar core circuit architecture, they exhibit profound functional differences whose mechanisms are unknown. Using intracellul...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.01.005
更新日期:2017-01-26 00:00:00
abstract::Immune responses involve coordination across cell types and tissues. However, studies in cancer immunotherapy have focused heavily on local immune responses in the tumor microenvironment. To investigate immune activity more broadly, we performed an organism-wide study in genetically engineered cancer models using mass...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.12.022
更新日期:2017-01-26 00:00:00
abstract::RNA-guided Cas9 endonucleases protect bacteria from viral infection and have been creatively repurposed as programmable molecular scalpels for surgical manipulation of DNA. Now, two papers in Cell (Pawluk et al. and Rauch et al.) identify viral proteins that suppress Cas9 and may function like molecular sheaths for th...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2016.12.007
更新日期:2017-01-12 00:00:00
abstract::Pathogenic Vibrio cholerae remains a major human health concern. V. cholerae has a characteristic curved rod morphology, with a longer outer face and a shorter inner face. The mechanism and function of this curvature were previously unknown. Here, we identify and characterize CrvA, the first curvature determinant in V...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.12.019
更新日期:2017-01-12 00:00:00
abstract::K-Ras is targeted to the plasma membrane by a C-terminal membrane anchor that comprises a farnesyl-cysteine-methyl-ester and a polybasic domain. We used quantitative spatial imaging and atomistic molecular dynamics simulations to examine molecular details of K-Ras plasma membrane binding. We found that the K-Ras ancho...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.11.059
更新日期:2017-01-12 00:00:00
abstract::CRISPR-Cas9 technology would be enhanced by the ability to inhibit Cas9 function spatially, temporally, or conditionally. Previously, we discovered small proteins encoded by bacteriophages that inhibit the CRISPR-Cas systems of their host bacteria. These "anti-CRISPRs" were specific to type I CRISPR-Cas systems that d...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2016.11.017
更新日期:2016-12-15 00:00:00
abstract::The elucidation of the genetic code remains among the most influential discoveries in biology. While innumerable studies have validated the general universality of the code and its value in predicting and analyzing protein coding sequences, established and emerging work has also suggested that full genome decryption m...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2016.09.022
更新日期:2016-12-15 00:00:00
abstract::Poorly immunogenic tumor cells evade host immunity and grow even in the presence of an intact immune system, but the complex mechanisms regulating tumor immunogenicity have not been elucidated. Here, we discovered an unexpected role of the Hippo pathway in suppressing anti-tumor immunity. We demonstrate that, in three...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.11.005
更新日期:2016-12-01 00:00:00
abstract::Francis' office window (at the Salk) commanded a panorama of the Pacific. "This grand natural scene was a physical correlate of Francis's intellectual world: wide-ranging, brilliantly lit, a little overawing, but also immensely inviting and above all an exciting place to be." (Mitchison, 2004). ...
journal_title:Cell
pub_type: 传,历史文章,杂志文章
doi:10.1016/j.cell.2016.11.008
更新日期:2016-12-01 00:00:00
abstract::The association of histone modification changes with autism spectrum disorder (ASD) has not been systematically examined. We conducted a histone acetylome-wide association study (HAWAS) by performing H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq) on 257 postmortem samples from ASD and matched control brai...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.10.031
更新日期:2016-11-17 00:00:00
abstract::Understanding how transcriptional enhancers control over 20,000 protein-coding genes to maintain cell-type-specific gene expression programs in all human cells is a fundamental challenge in regulatory biology. Recent studies suggest that gene regulatory elements and their target genes generally occur within insulated ...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2016.10.024
更新日期:2016-11-17 00:00:00
abstract::Who are science journalists, and how can journalists and research scientists work together to improve science communication? ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.10.051
更新日期:2016-11-17 00:00:00
abstract::Kinetochores connect centromeric nucleosomes with mitotic-spindle microtubules through conserved, cross-interacting protein subassemblies. In budding yeast, the heterotetrameric MIND complex (Mtw1, Nnf1, Nsl1, Dsn1), ortholog of the metazoan Mis12 complex, joins the centromere-proximal components, Mif2 and COMA, with ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.10.011
更新日期:2016-11-03 00:00:00
abstract::The dentate gyrus of the mammalian hippocampus continuously generates new neurons during adulthood. These adult-born neurons become functionally active and are thought to contribute to learning and memory, especially during their maturation phase, when they have extraordinary plasticity. In this Review, we discuss the...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2016.10.021
更新日期:2016-11-03 00:00:00
abstract::Spotted fever group (SFG) rickettsiae are human pathogens that infect cells in the vasculature. They disseminate through host tissues by a process of cell-to-cell spread that involves protrusion formation, engulfment, and vacuolar escape. Other bacterial pathogens rely on actin-based motility to provide a physical for...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.09.023
更新日期:2016-10-20 00:00:00
abstract::Metabolic activity is intimately linked to T cell fate and function. Using high-resolution mass spectrometry, we generated dynamic metabolome and proteome profiles of human primary naive T cells following activation. We discovered critical changes in the arginine metabolism that led to a drop in intracellular L-argini...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.09.031
更新日期:2016-10-20 00:00:00
abstract::Even a simple sensory stimulus can elicit distinct innate behaviors and sequences. During sensorimotor decisions, competitive interactions among neurons that promote distinct behaviors must ensure the selection and maintenance of one behavior, while suppressing others. The circuit implementation of these competitive i...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.09.009
更新日期:2016-10-20 00:00:00
abstract::The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous activation of B cell proliferation and drives the development of GC lymphomas in vivo. HVEM-deficient lymphoma B cells also induce a tumor-supportive microenvi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.08.032
更新日期:2016-10-06 00:00:00
abstract::Understanding human embryonic ventral midbrain is of major interest for Parkinson's disease. However, the cell types, their gene expression dynamics, and their relationship to commonly used rodent models remain to be defined. We performed single-cell RNA sequencing to examine ventral midbrain development in human and ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.09.027
更新日期:2016-10-06 00:00:00
abstract::A comprehensive analysis uncovered a set of yeast proteins promoting protein-based inheritance that shares many of the non-Mendelian properties of prions. Lacking any sequence or structural signatures of known prions, these proteins represent a new class of non-amyloid, protein-based epigenetic determinants that can c...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2016.09.036
更新日期:2016-10-06 00:00:00
abstract::Gene silencing is instrumental to interrogate gene function and holds promise for therapeutic applications. Here, we repurpose the endogenous retroviruses' silencing machinery of embryonic stem cells to stably silence three highly expressed genes in somatic cells by epigenetics. This was achieved by transiently expres...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.09.006
更新日期:2016-09-22 00:00:00
abstract::Many body surfaces harbor organ-specific γδ T cell compartments that contribute to tissue integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely expressing T cell receptor (TCR)-Vγ5 chains protect from cutaneous carcinogens. The DETC repertoire is shaped by Skint1, a butyrophilin-like (Btnl) gene express...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.08.030
更新日期:2016-09-22 00:00:00
abstract::For many scientific awards, such as Nobels and Laskers, the maximum number of recipients is three. This Rule of Three forces selection committees to make difficult decisions that increase the likelihood of singling out those individuals who open a new field and continue to lead it. The Rule of Three is reminiscent of ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.08.040
更新日期:2016-09-22 00:00:00
abstract::Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine development. VRC01-class bnAbs are important vaccine leads because their precursor B cells targeted by an engineered priming immunogen are relatively common among humans. This priming immunogen has demonstrated the ability to initiat...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.08.005
更新日期:2016-09-08 00:00:00
abstract::T cell dysfunction in cancer comes in many forms, with two new varieties reported in this issue. Daley et al. find that T cells expressing γδ T cell receptors (TCR) promote pancreatic tumor growth by inhibiting activation of T cells with conventional TCRs. Singer et al. characterize dysfunctional tumor infiltrating ly...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2016.08.058
更新日期:2016-09-08 00:00:00
abstract::Cellular compartments that cannot be biochemically isolated are challenging to characterize. Here we demonstrate the proteomic characterization of the synaptic clefts that exist at both excitatory and inhibitory synapses. Normal brain function relies on the careful balance of these opposing neural connections, and und...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.07.041
更新日期:2016-08-25 00:00:00